Ursolic Acid is a powerful plant-based compound found in apple skins, rosemary, holy basil, and oregano. It’s gaining recognition for its multi-pathway inhibition in cancer therapy—especially for its ability to block growth signals, stress mitochondria, and prevent metastasis.
In Protocol 2, Ursolic Acid is used strategically in the Metabolic Ignition Phase to intensify oxidative stress and impair tumor survival pathways—without blocking reactive oxygen species (ROS).
🔍 Ursolic Acid – Protocol 2 Summary
✅ Best Timing:
- 6:30 AM during the Metabolic Ignition Phase, fasted and antioxidant-free
- Only taken on OMAD days (not on full fasting days, due to GI side effects)
- Should be spaced at least 6 hours before any antioxidants (Vitamin C, Curcumin, etc.)
💊 Recommended Dose:
- 150 mg once daily in the morning stack
- Taken with MCT oil to improve bioavailability
- Lower dose avoids digestive upset while still reaching therapeutic levels
⏳ Active Duration in Body:
- Peak activity: 2–4 hours after ingestion
- Biological effects may last 6–8 hours
- Does not require buildup—effects are per-dose, especially oxidative and anti-proliferative functions
🔁 Redundancy With:
- Overlaps with Berberine in targeting PI3K/Akt/mTOR, but from different molecular angles
- Synergizes with Artemisinin, B17, and radiation via mitochondrial stress and ROS enhancement
- Avoid combining with strong anti-inflammatory supplements in the same phase
📉 Pathways Inhibited or Affected:
- PI3K/Akt/mTOR inhibition – suppresses growth, protein synthesis, survival
- EMT (epithelial–mesenchymal transition) – blocks invasion and metastasis
- Mitochondrial oxidative stress – promotes ROS accumulation and apoptosis
- Anti-angiogenesis – may restrict tumor blood supply
- Supports apoptosis via intrinsic mitochondrial pathways
🔒 Final Summary
Ursolic Acid is a growth-suppressing, metabolism-disrupting plant compound that hits cancer where it’s most vulnerable—its survival pathways and energy systems. Taken at 150 mg during the 6:30 AM Metabolic Ignition Phase, it amplifies oxidative stress, inhibits metastatic transformation, and weakens the cancer’s ability to adapt or spread.
Ursolic Acid serves as a potent enhancer of fasting, B17, and radiation therapy—but only when timed precisely and kept away from antioxidants.
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