What Is p53 and Why It Matters p53 is one of the most critical tumor suppressor proteins in human biology. Often called the “guardian of the genome,” p53 protects cells from becoming cancerous by monitoring DNA integrity, regulating metabolism, and controlling cell survival. Under normal conditions, p53 remains inactive at low levels. But when a … Continue reading p53 and Cancer: How the “Guardian of the Genome” Controls Tumor Survival