Cancer Protocols

25 Natural Compounds for Cancer That Act in the Digestive Tract

25 Natural Compounds for Cancer That Act in the Digestive Tract

Apricot Seeds (B17 / Amygdalin)

Apricot seeds are one of the most controversial yet widely discussed natural compounds for cancer, especially when it comes to digestive tract tumors. The core ingredient, amygdalin (often called B17), becomes active when it encounters the enzyme beta-glucosidase—found in higher concentrations inside cancer cells. Upon digestion, especially when the seeds are chewed and exposed to saliva, amygdalin breaks down and releases cyanide locally where tumors are present. While dangerous in high doses, this targeted effect can act like a chemical warfare agent inside the colon or stomach—harming cancer cells while leaving normal tissue relatively untouched due to its lower enzyme activity. Since amygdalin is poorly absorbed systemically, much of its activity remains in the gut lining, allowing prolonged exposure to digestive tumors. This direct cytotoxicity, combined with the induction of apoptosis, gives apricot seeds a special role among natural compounds for cancer that act in the gastrointestinal tract. For colorectal cancer in particular, it may offer an on-site apoptotic push.

Curcumin (from Turmeric)

Curcumin is one of the most studied natural compounds for cancer prevention and treatment. It shines especially in digestive tract cancers due to its poor absorption—a feature that becomes a strength in this context. When curcumin moves through the intestines, it binds directly to tumor cells in the colon and rectum, where it suppresses key growth and inflammation pathways such as NF-kB, STAT3, and COX-2. It also increases reactive oxygen species (ROS) in tumor cells, initiating oxidative damage that cancer cells cannot defend against when their glutathione levels are already low. Unlike other compounds that are absorbed too quickly to stay active in the gut, curcumin lingers—making prolonged contact with digestive tissues. This gives it time to act locally and block cancer-supporting microenvironments. While many people use black pepper extract (piperine) to enhance its absorption, those targeting gut tumors may intentionally avoid piperine to ensure curcumin stays in the intestines longer. For digestive cancers, it’s a foundational natural compound for cancer intervention.

Berberine

Berberine, a golden-yellow alkaloid found in plants like goldenseal and barberry, is gaining ground as one of the most powerful natural compounds for cancer. Its most impressive effects occur in the gut, where it stays active longer due to its relatively low bioavailability. Berberine disrupts cancer cell energy production by targeting mitochondria and activating AMPK—an energy sensor that halts cancer cell growth. It also inhibits glucose metabolism, starving tumors that depend on sugar for survival. In the digestive tract, berberine acts like a sniper: it slows tumor growth, induces apoptosis, and even changes the local microbiome to be less cancer-friendly. In high doses, its presence in the intestinal lumen increases, allowing direct contact with tumors in the colon or stomach. This localized effect, combined with its metabolic disruption, places berberine among the top natural compounds for cancer that act right where digestive tumors reside. It’s especially relevant in protocols that seek to starve and oxidize colorectal tumors simultaneously.

Quercetin

Quercetin is a flavonoid found in apples, onions, and capers—yet its cancer-fighting potential goes well beyond nutrition. As one of the most powerful natural compounds for cancer control in the gut, quercetin blocks multiple pathways that support tumor survival. These include PI3K/AKT/mTOR and Wnt/β-catenin—two of the most aggressive signaling routes used by colorectal cancer to grow and resist treatment. What makes quercetin especially effective in the digestive tract is its poor absorption. Instead of quickly entering the bloodstream, it stays behind in the intestines, where it can bind to tumor cells directly. Quercetin also creates a paradoxical effect: while it’s an antioxidant in healthy cells, it becomes pro-oxidative in cancer cells, creating ROS and damaging their mitochondria. This dual action makes it a versatile tool. For those fighting digestive tract cancers like rectal or colon tumors, quercetin acts like a suppressive blanket—disrupting inflammation, starving tumors, and encouraging apoptosis in direct-contact situations.

EGCG (Green Tea Extract)

Epigallocatechin gallate (EGCG), the active polyphenol in green tea, stands out as one of the most researched natural compounds for cancer—especially for its action in the digestive tract. When consumed without food, EGCG can bind to epithelial cells in the colon, creating a coating effect that stays active as the compound passes through. Its ability to produce ROS (reactive oxygen species) in tumor cells makes it lethal under the right conditions—particularly when glutathione is depleted. EGCG also inhibits angiogenesis (the creation of new blood vessels) and disrupts iron metabolism in cancer cells, which often rely on excess iron to grow. What sets EGCG apart in digestive cancer strategies is its physical interaction with the gut lining. Because it doesn’t absorb quickly, it remains in the GI tract longer, maximizing its time in contact with tumors. Whether targeting stomach cancer or colon polyps, EGCG is a cornerstone compound for protocols aimed at local oxidative stress and tumor suppression.

Artemisinin (Sweet Wormwood)

Artemisinin, derived from the sweet wormwood plant (Artemisia annua), is one of the few natural compounds for cancer that becomes more lethal in the presence of iron. This makes it especially effective in the colon, where many tumors are iron-rich due to cancer’s increased demand for this metal. Artemisinin reacts with iron to form free radicals that destroy cancer cells through oxidative stress. The beauty of this compound lies in its ability to behave like a guided missile—triggering cell death only in environments where cancer cells hoard iron, leaving healthy cells mostly unaffected. When taken with MCT oil or other healthy fats, artemisinin’s absorption is optimized in digestive tissues, allowing it to linger longer in contact with tumor sites. For colorectal and gastric cancers, this makes artemisinin one of the most precise oxidative tools in a natural cancer protocol. Its dual action—oxidation plus selective activation—cements its place among the most effective natural compounds for cancer within the digestive tract.

Sulforaphane (from Broccoli Sprouts)

Sulforaphane, found in cruciferous vegetables like broccoli sprouts, works like a detox grenade in the colon. It activates phase II detoxification enzymes, supports glutathione recycling, and induces apoptosis in cancer cells—especially in the early stages of colon carcinogenesis. As one of the top natural compounds for cancer prevention and intervention, sulforaphane also inhibits histone deacetylase (HDAC), modifying gene expression to stop tumors from multiplying. It’s particularly potent when consumed raw or lightly cooked, as this preserves its active precursor, glucoraphanin, which gut bacteria convert to sulforaphane. Since much of this transformation happens directly in the colon, sulforaphane is perfectly suited for local action against polyps, adenomas, and developing cancers in the gut lining. Its ROS-generating effects, combined with its anti-inflammatory and gene-silencing capabilities, make sulforaphane a triple threat. For those targeting colorectal cancer using natural compounds for cancer intervention, sulforaphane offers both prevention and on-site attack.

Pancreatic Enzymes (Pancreatin, Trypsin, Chymotrypsin)

Pancreatic enzymes like pancreatin, trypsin, and chymotrypsin aren’t just for digestion—they’re also natural compounds for cancer that dissolve the protective barriers cancer cells use to hide. Tumors often produce fibrin coatings or embed themselves in mucin to avoid immune detection. These enzymes strip away that armor. When taken on an empty stomach, they aren’t used for food digestion—they stay active in the digestive tract and may reach tumors, especially in the colon and rectum, where they can break down extracellular matrix proteins. This exposes cancer cells to immune attack and enhances the effect of oxidative therapies. Enzymes also may help reduce inflammation in the gut, preventing future polyp formation. When combined with other contact-based compounds like curcumin or quercetin, enzymes can act as primers—clearing the path for other agents to attack tumor cells more effectively. As such, they are essential in any digestive cancer strategy involving natural compounds for cancer that target tumors on contact.

MCT Oil (Carrier Agent)

While not an anticancer agent by itself, MCT oil (medium-chain triglycerides) is a critical delivery system that enhances the potency of many other natural compounds for cancer. MCTs are rapidly absorbed by the intestinal lining and transported directly to the liver via the portal vein, making them excellent carriers for fat-soluble compounds like artemisinin, honokiol, and fenbendazole. By binding with these agents, MCT oil improves their absorption in the gut mucosa, allowing for deeper penetration into gastrointestinal tissues. This is particularly important for tumors located in the colon or stomach lining, where contact exposure is key. MCT oil also promotes ketosis, depriving cancer cells of glucose and creating an environment where oxidative therapies work more effectively. It’s a stealth strategy: while MCT doesn’t attack cancer itself, it supercharges the compounds that do. For any protocol targeting digestive tract tumors, pairing MCT with natural compounds for cancer enhances the local impact while improving metabolic conditions systemically.

Honokiol

Honokiol, a polyphenol from magnolia bark, disrupts cancer cells by targeting their mitochondria, causing them to self-destruct through oxidative stress. It has poor water solubility and is absorbed slowly, making it a prime candidate for gut-localized contact when taken in high oral doses. Honokiol has been shown to inhibit tumor-promoting pathways like NF-kB and STAT3, while also suppressing genes that drive metastasis. Its anti-inflammatory and antioxidant profile supports healthy tissues but paradoxically generates ROS inside cancer cells—an ideal profile for selectively damaging tumors in the GI tract. Its prolonged presence in the digestive tract allows it to engage with cancer cells in the colon, stomach, or intestines without rapid clearance. Honokiol is one of the more potent yet lesser-known natural compounds for cancer that targets tumors where they live—especially when paired with a fat source like MCT oil to enhance tissue penetration. It’s an elegant tool in oxidative, contact-based protocols.

Boswellia Serrata (Frankincense)

Boswellia serrata, commonly known as frankincense, is more than a spiritual resin—it’s a biologically active anti-inflammatory powerhouse. In the digestive tract, it acts like a localized flame extinguisher, especially for tumors embedded in inflamed tissues. Boswellic acids, its active compounds, inhibit the 5-lipoxygenase (5-LOX) pathway, which cancer uses to drive chronic inflammation and tumor progression. This makes it especially useful for colorectal cancers that exist in a pro-inflammatory gut environment. Due to moderate absorption, boswellic acids remain in the gut longer, giving them time to act directly on tumor sites. Studies suggest they may shrink colon polyps and inhibit angiogenesis—cutting off a tumor’s blood supply. Boswellia also supports mucosal healing, reducing cancer’s ability to invade healthy cells nearby. In protocols that target digestive cancers using natural compounds for cancer, Boswellia is often paired with curcumin for synergistic anti-inflammatory and apoptotic effects. Its dual action—tumor suppression and mucosal protection—makes it ideal for long-term gut recovery and tumor control.

Probiotics (Butyrate-Producing Strains like Clostridium butyricum)

Probiotics may not seem like a cancer-fighting weapon at first glance, but specific strains that produce butyrate are direct-contact agents in the war against colon cancer. Butyrate is a short-chain fatty acid formed by the fermentation of fiber in the colon. What makes it special? It’s a natural HDAC inhibitor, which means it changes gene expression in cancer cells—turning off survival pathways and triggering apoptosis. Unlike other compounds that must be swallowed, absorbed, or metabolized, butyrate is created directly inside the colon, precisely where tumors form. Strains like Clostridium butyricum and Faecalibacterium prausnitzii produce therapeutic butyrate when fed soluble fibers. Among all natural compounds for cancer used in digestive protocols, butyrate is one of the few that ferments into existence exactly where it’s needed. It also supports healthy immunity, tightens the gut barrier, and reduces inflammation. For colon-specific tumors, butyrate-producing probiotics are more than supportive—they’re essential.

Rutin (Quercetin Precursor)

Rutin is a glycosylated flavonoid—essentially a plant-based compound that the body can convert into quercetin. What makes rutin unique among natural compounds for cancer is its slow breakdown during digestion, which allows it to travel deeper into the colon. Once there, it gradually releases quercetin, providing extended contact time with tumor tissues. This slow-release property is valuable for rectal or sigmoid colon tumors, where continuous exposure is key to suppressing pathways like PI3K/AKT and Wnt/β-catenin. Rutin also has antioxidant and anti-inflammatory properties, but like quercetin, it behaves paradoxically by triggering oxidative stress inside cancer cells. Its presence in the gut also helps reduce angiogenesis and may help shrink polyps. Because it travels further into the lower GI tract before activation, rutin is an ideal add-on in protocols that use natural compounds for cancer to create sustained, contact-based suppression. It’s especially useful when used with digestive enzymes or taken on an empty stomach.

Diosmetin

Diosmetin is a citrus-based flavonoid that shares many properties with quercetin but has one special advantage: extremely low absorption, which allows it to linger in the gut for prolonged direct action. It interferes with cancer growth by inhibiting the ERK and PI3K/AKT pathways and inducing both apoptosis and autophagy, a process where cancer cells begin digesting themselves under stress. Diosmetin’s role as a contact-based anticancer agent comes from its ability to physically bind with the epithelial lining of the intestines, directly affecting localized tumor cells. In colon cancer models, diosmetin has been shown to suppress cell proliferation, block inflammation, and reduce angiogenesis. Since it stays in the digestive tract longer than many other flavonoids, it’s particularly useful for colorectal cancer strategies focused on on-site oxidative and apoptotic pressure. Among the arsenal of natural compounds for cancer, diosmetin stands out as a non-systemic option that’s gentle on the body but aggressive toward tumors in the gut.

IP6 (Inositol Hexaphosphate)

IP6, or inositol hexaphosphate, is a naturally occurring molecule found in high-fiber foods like rice bran and legumes. What makes it powerful against cancer is its ability to chelate iron and zinc, depriving cancer cells of the metals they rely on for replication and defense. It also activates NK cells and enhances the body’s immune response. But in the digestive tract, IP6 operates like a localized chelation and oxidation agent. It latches onto iron in the colon, creating a redox imbalance that leads to cancer cell apoptosis. Because IP6 is not rapidly absorbed, it remains active in the gut longer, making it a powerful tool for direct contact action against gastrointestinal tumors. It also interferes with the PI3K/AKT signaling pathway, suppressing cancer cell proliferation. When used with fasting or iron-restricted diets, IP6 becomes even more potent. It’s one of the most strategic natural compounds for cancer when gut-targeted depletion and oxidative therapy are the goals.

Chlorogenic Acid (from Coffee)

Chlorogenic acid, a polyphenol found in coffee, is gaining attention for its contact-based cancer-fighting abilities in the digestive system. It serves dual roles: first, as an antioxidant, and second, as a pro-oxidant within the cancer cell environment. In the gut, especially the colon, chlorogenic acid generates reactive oxygen species (ROS) that damage cancer cell membranes while preserving healthy tissue. Its absorption is moderate, which allows it to linger in the digestive tract long enough to make direct contact with tumor cells. It also inhibits key cancer-supporting pathways like NF-kB and STAT3, making it harder for tumors to maintain inflammation and growth signals. Some evidence suggests that chlorogenic acid may suppress angiogenesis and even improve immune recognition of tumor cells. For colorectal and gastric cancers, it can serve as a passive but persistent threat to cancer cells. When included in a protocol focused on natural compounds for cancer, chlorogenic acid becomes an easily accessible, low-cost addition with measurable local effects in the gut.

Resveratrol

Resveratrol, a polyphenol most famously found in grapes and red wine, has strong anticancer effects that extend into the digestive tract—particularly when taken in high oral doses. Its poor bioavailability is often seen as a drawback, but when targeting colon or rectal cancers, this limitation becomes a therapeutic advantage. Resveratrol remains longer in the intestines, where it exerts direct effects on tumor cells by inducing apoptosis, inhibiting PI3K/AKT and Wnt/β-catenin pathways, and producing ROS in tumor microenvironments. It also helps starve tumors of blood supply by reducing angiogenesis. Its anti-inflammatory properties make it useful for tumors in inflamed colonic tissues, where it may shrink lesions and prevent new ones from forming. As a natural compound for cancer, resveratrol’s prolonged contact with digestive tract tumors allows it to act continuously and locally without the need for systemic saturation. In the context of fasting, ketogenic diets, or glutathione-depletion phases, its effects may be even more pronounced.

Gingerol (from Ginger)

Gingerol, the spicy compound that gives ginger its kick, also gives it powerful anticancer abilities—particularly in the digestive system where ginger is often used to soothe inflammation. Gingerol induces apoptosis by activating oxidative stress inside cancer cells, while at the same time suppressing key inflammatory pathways like NF-kB and COX-2. These combined effects make gingerol a rare example of a compound that calms healthy tissue while attacking malignant cells. Its bioavailability is low to moderate, meaning it spends a considerable amount of time inside the gastrointestinal tract before being metabolized. This extended contact period allows gingerol to interact directly with tumors in the colon, rectum, and stomach. It may also modulate gut microbiota in ways that make the environment less hospitable to tumor growth. As a natural compound for cancer, gingerol is both accessible and versatile—working on inflammation, oxidation, and cancer signaling at once. For those using contact-based therapy in digestive cancers, ginger is more than just a soothing spice.

Capsaicin (from Chili Peppers)

Capsaicin, the compound responsible for the heat in chili peppers, has a surprisingly powerful role in cancer therapy when used strategically. It works by generating ROS inside tumor cells, disrupting their mitochondrial membranes, and causing apoptosis. It also targets the PI3K/AKT and STAT3 pathways—two key drivers of tumor resistance and survival. In the gut, capsaicin stays active longer due to slower absorption, giving it time to bind directly to tumor cells in the colon or stomach lining. It can also inhibit angiogenesis and reduce chronic inflammation—conditions that often accompany digestive cancers. Despite its spicy nature, capsaicin can be micro-dosed effectively in protocols involving other natural compounds for cancer, amplifying oxidative pressure inside tumors. Some users incorporate it through capsules or tinctures, while others tolerate it in food form. When used wisely, capsaicin becomes a fiery tool for inducing cancer cell death while leaving healthy cells relatively unharmed in the digestive tract.

Piperine (from Black Pepper)

Piperine is best known as the compound that boosts the bioavailability of other supplements—especially curcumin—but it’s also a mild anticancer agent in its own right. In the gut, piperine can help keep other anticancer compounds like quercetin and resveratrol present longer, ensuring they spend more time in direct contact with tumors. Piperine also targets cancer growth pathways like NF-kB, induces apoptosis, and enhances ROS formation inside tumor cells. Its absorption is moderate, and its effects can be tailored depending on the therapeutic goal: if systemic action is needed, piperine helps compounds absorb; if local action is preferred, it can be omitted to let those compounds linger in the digestive tract. Still, piperine itself has shown promising results in colon cancer models due to its direct suppression of cancer signaling and modest ROS production. When paired intelligently, piperine can be an amplifying agent in any stack of natural compounds for cancer, especially those focused on oxidative stress in the digestive system.

21. Luteolin

Luteolin is a yellow flavonoid found in celery, parsley, chamomile, and thyme. It stands out among natural compounds for cancer because of its ability to suppress inflammation, promote apoptosis, and inhibit angiogenesis—all critical for controlling tumors in the digestive tract. Luteolin interferes with several cancer-promoting pathways, including PI3K/AKT, Wnt/β-catenin, and MAPK/ERK. Its low bioavailability, typically seen as a drawback, actually benefits those targeting colorectal or gastric cancers, as luteolin remains active longer in the intestines. It also functions as a CD38 inhibitor, preserving NAD+—a molecule vital for immune cell function and mitochondrial repair. In the gut, luteolin lingers on the mucosal surfaces, binding to tumor cells and disrupting their redox balance. This makes it especially valuable during recovery phases when immune surveillance is needed to prevent recurrence. When included in a stack of natural compounds for cancer, luteolin adds both frontline and support-layer value, enhancing both contact-based effects and immune resilience.

22. Apigenin

Apigenin, most abundant in chamomile and parsley, is a powerful flavonoid known for its dual effects: calming inflammation and disrupting cancer cell signaling. Among natural compounds for cancer, apigenin is one of the most well-balanced—capable of targeting key tumor pathways (PI3K/AKT, ERK/MAPK) while also inducing apoptosis through ROS production. In the digestive tract, apigenin remains present in the colon and small intestine longer than more rapidly absorbed compounds, making it an excellent candidate for on-contact tumor suppression. It has also been shown to enhance the effects of chemotherapy and radiation in colon cancer models, particularly when administered during oxidative therapy windows. Apigenin helps normalize the tumor microenvironment by reducing inflammation and oxidative stress in healthy cells while increasing those same stressors in malignant ones. Its ability to promote autophagy also makes it useful during fasting-based cancer protocols. Apigenin is one of the most adaptable and gut-friendly natural compounds for cancer in a holistic treatment strategy.

23. Ellagic Acid (from Pomegranate)

Ellagic acid is a polyphenol primarily found in pomegranates, berries, and walnuts. It has gained recognition among natural compounds for cancer due to its strong anti-proliferative, anti-inflammatory, and ROS-generating properties. In the digestive tract, ellagic acid slows down the growth of cancer cells by inducing apoptosis, inhibiting angiogenesis, and suppressing signaling pathways like NF-kB and Wnt/β-catenin. Its low systemic absorption means it stays in the GI tract longer, giving it more opportunity to interact with tumors in the colon or stomach. Ellagic acid also supports immune surveillance by reducing oxidative damage to healthy tissues while destabilizing cancer cell membranes. Some studies show that ellagic acid can work synergistically with quercetin and resveratrol, especially when all are consumed in a low-carb, antioxidant-replenishing meal. Its ability to enhance redox imbalance in cancer cells while calming inflammation in healthy ones makes ellagic acid one of the more sophisticated natural compounds for cancer targeting the digestive tract.

24. Ursolic Acid (from Apple Peels)

Ursolic acid, a triterpenoid compound found in apple peels, rosemary, and holy basil, is a multi-targeted natural compound for cancer—especially effective in the gut. It acts as a mitochondrial disruptor, apoptosis inducer, and inflammation regulator. In the digestive tract, ursolic acid exerts contact-based cytotoxic effects by generating ROS and inhibiting cancer growth pathways like PI3K/AKT and STAT3. It also interferes with tumor invasion by weakening the cancer cells’ ability to adhere to and penetrate the colon wall. Due to limited absorption, ursolic acid stays longer in the gut, allowing for extended interaction with tumor cells in the colon and rectum. It has even shown potential in reducing tumor size in colon cancer models when combined with curcumin or resveratrol. Ursolic acid also helps maintain muscle mass during fasting and caloric restriction, supporting metabolic health during cancer therapy. For protocols focused on natural compounds for cancer with on-contact digestive effects, ursolic acid is a high-impact addition.

25. Silymarin (from Milk Thistle)

Silymarin is a flavonoid complex extracted from milk thistle, widely known for liver protection but also valuable in the cancer space. In the digestive tract, silymarin inhibits cancer progression by reducing inflammation, blocking angiogenesis, and inducing apoptosis through oxidative stress. It targets key cancer pathways like NF-kB and STAT3, which are often upregulated in colorectal and gastric cancers. Its moderate absorption allows it to remain present in the gut lining for extended periods, enhancing its potential for direct interaction with tumor tissue. Silymarin also supports glutathione recycling, providing a unique benefit during antioxidant recovery phases, but it can also become pro-oxidative in the cancer microenvironment. It synergizes well with other natural compounds for cancer such as quercetin, curcumin, and EGCG. For digestive cancers, especially in the liver-adjacent GI tract, silymarin acts as both a protector and a targeted attacker—offering double value in any natural cancer strategy focused on digestive health.

✅ Final Summary

This comprehensive review of 25 natural compounds for cancer reveals a potent arsenal of plant-based and nutraceutical compounds that act directly on tumors in the digestive tract. Their value lies not only in their biochemical power but in their timing, bioavailability, and direct contact with cancerous tissues. From the powerful oxidative effects of artemisinin to the microbial fermentation of butyrate-producing probiotics, each compound plays a unique role in weakening cancer defenses. Whether you’re building a protocol from scratch or optimizing an existing one, understanding how these compounds behave locally in the gut can help you choose what matters most. Always consult a licensed health provider before beginning any treatment, and use this guide for informational purposes only.

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The foundation of cancer

  1. Apricot Seeds (B17 / Amygdalin)
  2. Curcumin (from Turmeric)
    • Source: Curcumin—From Molecule to Biological Function
    • Relevance: Highlights curcumin’s anti-inflammatory and ROS-inducing effects, with specific mention of colorectal cancer inhibition via NF-kB and STAT3 pathways.
    • Note: Includes clinical trial references for colorectal cancer.
  3. Berberine
  4. Quercetin
  5. EGCG (Green Tea Extract)
  6. Artemisinin / Sweet Wormwood
  7. Sulforaphane (from Broccoli Sprouts)
  8. Pancreatic Enzymes (Pancreatin, Trypsin, Chymotrypsin)
    • Source: Enzyme Therapy in Oncology: A Review
    • Relevance: Explores pancreatic enzymes’ ability to degrade cancer cell protein coats, potentially enhancing apoptosis in digestive tract tumors.
    • Note: Limited direct studies; focuses on general oncology applications.
  9. MCT Oil (as a Carrier)
  10. Honokiol
  11. Boswellia Serrata (Frankincense)
  12. Probiotics (Butyrate-Producing Strains like Clostridium butyricum)
  13. Rutin (Quercetin Precursor)
  14. Diosmetin
  15. IP6 (Inositol Hexaphosphate)
  16. Chlorogenic Acid (from Coffee)
  17. Resveratrol
  18. Gingerol (from Ginger)
  19. Capsaicin (from Chili Peppers)
    • Source: Capsaicin and Its Effects on Cancer
    • Relevance: Discusses capsaicin’s ROS generation and apoptosis induction in colorectal cancer cells.
    • Note: Includes in vitro and in vivo studies.
  20. Piperine (from Black Pepper)
  21. Luteolin
  22. Apigenin
  23. Ellagic Acid (from Pomegranate)
    • Source: Ellagic Acid and Cancer Prevention
    • Relevance: Discusses ellagic acid’s inhibition of casein kinase II and apoptosis induction in colorectal cancer.
    • Note: Strong preclinical data.
  24. Ursolic Acid (from Apple Peels)
  25. Silymarin (from Milk Thistle)
25 Natural Compounds That Target Digestive Tract Cancer
Natural Compounds, Cancer, Digestive