Andrographis paniculata is a bitter herb used in traditional medicine systems like Ayurveda and Traditional Chinese Medicine for centuries. The plant’s active compound, andrographolide, has drawn increasing interest in modern oncology and immunology research. Studies show it may suppress cancer-promoting pathways, stimulate immune defense, and help regulate inflammation—making it a strategic part of cancer recovery protocols.
🧪 How Andrographis Works
Unlike single-target drugs, andrographolide operates on multiple fronts:
- It enhances immune surveillance by activating T-cells and natural killer (NK) cells.
- It reduces chronic inflammation in the tumor environment by suppressing key inflammatory cytokines.
- It directly inhibits tumor cell survival by interfering with growth pathways like PI3K/Akt/mTOR and JAK/STAT.
- It helps prevent angiogenesis (new blood vessel formation), which tumors use to feed themselves.
- It even shows anti-viral and antimicrobial effects, adding another layer of protection during immune-compromised periods.
In Protocol 2, Andrographis is used during the Antioxidant Wave Phase to help transition the body from destruction mode to deep recovery.
🔍 Andrographis – Protocol 2 Summary
✅ Best Timing:
- 12:30 PM during the Antioxidant Wave Phase
- Avoid taking within 4–6 hours of oxidative agents like B17, radiation, Artemisinin, or Methylene Blue
💊 Recommended Dose:
- 1000 mg once daily, standardized to at least 10% andrographolide
- Take with food or fat to improve bioavailability
- May be split (500 mg AM/500 mg PM) in cases of chronic inflammation, but once daily is sufficient in Protocol 2
⏳ Active Duration in Body:
- Onset within 1–2 hours
- Immune and anti-cancer effects last 6–10 hours
- Builds cumulative benefits with daily use
🔁 Redundancy With:
- Synergistic with Cat’s Claw, Turkey Tail (immune activation)
- Overlaps with Curcumin, Quercetin, and Luteolin in anti-inflammatory action
- Unique for its strong immune signaling activation and multi-pathway cancer inhibition
📉 Pathways Inhibited or Affected:
- NF-κB inhibition – dampens chronic inflammation
- JAK/STAT suppression – blocks cancer cell immune escape
- PI3K/Akt/mTOR inhibition – slows growth and encourages apoptosis
- VEGF downregulation – reduces blood vessel formation to tumors
- Immune enhancement – boosts T-cell and NK cell response
🔒 Final Summary
Andrographis is a powerful herbal multitasker that helps clean up the aftermath of cancer cell death and restore immune control. In Protocol 2, it plays a recovery-phase role at 12:30 PM to:
- Shut down residual inflammation
- Prevent tumor regrowth
- Rebuild immune strength
- Guard against infections
At 1000 mg daily, Andrographis helps fortify the immune system and enhances the cancer-fighting synergy of Protocol 2’s antioxidant phase—without interfering with oxidative kill strategies.
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