Fisetin is a natural flavonoid found in strawberries, apples, and onions. It has gained attention in cancer research for its powerful senolytic and anti-inflammatory effects. As a senolytic, Fisetin helps clear out senescent or “zombie” cells—damaged cells that linger in the body, fueling inflammation, immune dysfunction, and cancer progression.

In cancer recovery protocols like Protocol 2, Fisetin plays a key role in the Antioxidant Wave Phase by:

• Eliminating precancerous and senescent cells
• Suppressing inflammation and oxidative stress
• Protecting NAD+ reserves by inhibiting CD38
• Supporting immune recovery and post-radiation healing

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🔍 Fisetin – Cancer Recovery Summary

✅ Best Timing:

• 12:30 PM during the Antioxidant Wave Phase
• Take after all oxidative therapies (radiation, B17, Artemisinin)
• Optionally split: 750 mg at 12:30 PM + 750 mg with OMAD (~2:30 PM)

🚫 Avoid during oxidative kill windows (morning fasted phase), as Fisetin is antioxidant and may interfere with ROS-based therapies.

💊 Recommended Dose:

• 1500 mg/day, taken with food or healthy fats
• Use a high-purity extract (≥98% Fisetin) for therapeutic potency
• Adjust based on tolerance or gut sensitivity

⏳ Active Duration in Body:

• Onset: 1–2 hours after ingestion
• Effect duration: 6–8 hours
• Cumulative effects: Build over weeks with consistent use

🔁 Redundancy With:

• Overlaps with Quercetin, Apigenin (senolytic + CD38 inhibition)
• Synergistic with Resveratrol and EGCG (supports NAD+ and immune pathways)
• Avoid combining with oxidative agents in the same 6–8 hr window

📉 Pathways Inhibited or Affected:

• CD38 suppression – Preserves NAD+ for T-cell and NK cell energy
• NF-κB downregulation – Reduces inflammation and cytokine load
• mTOR inhibition – Promotes autophagy and cellular repair
• Senolytic clearance – Removes aging cells that fuel relapse
• PI3K/Akt inhibition – Slows tumor growth and boosts apoptosis

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🔒 Final Summary

Fisetin is a cancer-fighting cleanup crew. By targeting and removing senescent cells, it helps your immune system recover from chemo, radiation, and metabolic stress. In Protocol 2, it’s taken during the Antioxidant Wave (12:30 PM) to protect immune cells, preserve mitochondrial NAD+, and clear debris that would otherwise fuel cancer recurrence.

At 1500 mg/day, Fisetin is a powerful part of the post-strike recovery stack—especially in cancers with high inflammation, CD38 overexpression, or NAD+ depletion.

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