The Foundation of Metabolic Cancer Therapy: Attack Phase

When it comes to killing cancer effectively, timing is everything. That’s the principle behind the “Attack Phase” in our radiation protocol. This carefully timed morning stack combines metabolic disruptors that enhance the killing power of radiation by up to 2–3.5x, according to preclinical research and real-world case reports. This metabolic approach targets cancer cells when they’re most vulnerable: fasted, low in glucose, and stripped of antioxidant defenses (Safdie et al., 2009).

Why Radiation Needs Help

Radiation alone is powerful, but it’s not perfect. It relies on generating reactive oxygen species (ROS) to damage cancer DNA, but tumors often resist radiation by boosting their internal antioxidants like glutathione and NAD+. The Attack Phase strips away these defenses, unleashing oxidative chaos and turning radiation into a much more lethal weapon (Raffaghello et al., 2008).

Fasted State: Starving the Enemy

The Attack Phase begins after a water fast and metabolic preparation. In this fasted state, blood sugar and insulin are low, glutathione is suppressed, and healthy cells enter protective autophagy. Cancer cells, which rely heavily on glucose (the Warburg Effect) — become stressed, energy-starved, and unable to handle extra ROS. This makes them highly sensitive to radiation damage (Safdie et al., 2009).

Methylene Blue — The Redox Trigger

At the heart of the stack is Methylene Blue, a redox cycler that increases mitochondrial stress and amplifies ROS during radiation. When taken in a moderate dose (e.g. 200 mg), it pushes oxidative stress beyond what cancer cells can survive — especially when combined with red light or radiation. Studies show that MB can increase radiosensitivity by 30–60% on its own.(Zhu et al., 2021).

Ivermectin — Disarming Cancer’s Repair Crew

Ivermectin isn’t just an anti-parasitic drug. In cancer therapy, it disrupts DNA repair mechanisms and WNT/β-catenin signaling, both of which are vital for cancer survival post-radiation. Ivermectin also induces mitochondrial dysfunction, helping radiation overwhelm the cancer cell’s ability to recover. Estimated radiosensitization boost: +25–50%.(Li et al., 2022).

Berberine — Metabolic Warfare

Berberine hits cancer’s metabolism at its core by activating AMPK, lowering glucose uptake, and suppressing mTOR. These changes reduce energy availability for DNA repair, and increase ROS generation. Berberine mimics metformin, but with additional anti-inflammatory and ferroptosis-enhancing benefits. Estimated radiation synergy: +20–40%.(Yang et al., 2018).

Fenbendazole — Collapsing the Cytoskeleton

Originally used as a dewormer, Fenbendazole disrupts microtubule function in cancer cells, blocking mitosis and preventing structural recovery. It also lowers glutathione, which makes radiation far more deadly. In animal studies, fenbendazole and radiation have shown powerful synergistic effects, adding +20–30% to kill rates.(Dogra et al., 2018).

Artemisinin — The Iron-Activated Killer

Artemisinin, derived from sweet wormwood, is activated by iron and creates deadly free radicals. Cancer cells hoard iron, making them perfect targets for artemisinin-based ferroptosis. When combined with radiation, the oxidative burst is magnified dramatically. Estimated boost: +30–70% depending on tumor iron load.(Efferth et al., 2019).

Lactoferrin — Starving Cancer of Iron

Iron is a double-edged sword: cancer needs it to grow but also becomes vulnerable to oxidative death when overloaded. Liposomal lactoferrin helps by binding excess iron, limiting cancer cell growth and increasing sensitivity to ROS stress. It supports artemisinin’s effect without blunting the radiation response.(Actor et al., 2009).

Other Supportive Attack Compounds

Compounds like Ursolic Acid, Cat’s Claw, Bupleurum, and Pancreatin Enzymes each contribute uniquely to this pre-radiation kill stack. Ursolic acid suppresses PI3K/Akt/mTOR, Cat’s Claw weakens DNA repair, Bupleurum modulates inflammation, and enzymes dissolve protective tumor membranes.

The Role of Omega-3 and MCT Oil

Omega-3 fatty acids promote lipid peroxidation, a core feature of ferroptosis (Doll et al., 2017), while MCT oil enhances absorption of lipophilic compounds like MB, fenbendazole, and artemisinin. These dietary components are essential tools for pushing oxidative damage past the cancer cell’s tipping point.

Why We Exclude Antioxidants During This Attack Window

Any antioxidant taken during this window — like Vitamin C or IP6 — would neutralize ROS and protect cancer cells from the oxidative damage radiation is trying to induce. That’s why all antioxidants are delayed until after the oxidative kill window (usually around 12:30 PM). Timing is critical.

Cumulative Kill Power: 2× to 3.5× Boost (But It Depends!)

Based on these combined radiosensitizers, your Attack Phase may increase radiation effectiveness by 150–250%, especially when done in a fasted, low-glucose state with no antioxidants to blunt ROS. This estimate aligns with preclinical synergy data and real-world case protocols.

👉 But remember: Your actual kill rate can vary depending on where your tumor is, how much organ, fat, or bone obstruction the radiation beam must penetrate, and whether any healthy tissues limit the dose intensity. Tumors deeply embedded behind bone or fat tissue may absorb less direct ROS damage, while tumors near the surface with minimal shielding can be hit harder.

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This is why many patients in Protocol 2 or Protocol 2 Lite also use metabolic stacking (fasting, oxidative stress, iron modulation) to weaken tumor defenses from the inside, making whatever radiation gets through much more lethal.

The Science Is on Our Side

Each component of the Attack Phase is backed by peer-reviewed studies, real-world case reports, and mechanistic data. While no single supplement guarantees success, their combined synergy creates a kill trap that radiation alone cannot match. This approach strikes hard while the cancer is metabolically cornered.

Summary — Why the Attack Phase Matters

Radiation therapy isn’t just about zapping a tumor — it’s about creating the right conditions so the tumor can’t fight back. The Attack Phase ensures that cancer cells are deprived of fuel, stripped of antioxidants, overrun with ROS, and unable to repair. For anyone serious about a natural cancer therapy that works with radiation, this morning stack could be the most important part of their healing protocol.

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