Diosmetin is a citrus-derived flavonoid found in oranges and lemons. It is the active aglycone form of diosmin, known for its anti-inflammatory, anti-proliferative, and CD38-inhibiting properties. Diosmetin is structurally related to Apigenin but has a longer half-life and stronger influence on NAD+ preservation pathways.
In Protocol 2, Diosmetin is taken during the Antioxidant Wave Phase to:
- Protect NAD+ levels in immune and mitochondrial cells
- Inhibit inflammation and growth signals
- Support DNA repair and immune recovery following radiation or oxidative strike therapies
π Diosmetin β Protocol 2 Summary
β Best Timing:
- 12:30 PM during the Antioxidant Wave Phase
- Taken with other flavonoid antioxidants (Fisetin, Quercetin, Resveratrol)
- Do not take during the oxidative kill window or within 6 hours of B17, Artemisinin, or radiation
π Recommended Dose:
- 900 mg once daily, taken with food or healthy fats to enhance absorption
- High-purity Diosmetin extract preferred over diosmin
- May be paired with Apigenin for stronger CD38/NAD+ protection, though combined dosing should be monitored for tolerance
β³ Active Duration in Body:
- Onset of effects within 1β2 hours
- Biological and immune-modulating effects last 8β12 hours
- Longer half-life than many flavonoids, making it ideal for sustained NAD+ support during recovery
π Redundancy With:
- Overlaps with Apigenin and Fisetin in CD38 inhibition β may rotate or stagger across days if using all three
- Complements Resveratrol and EGCG for NAD+ and SIRT1 support
- Avoid during oxidative therapy phases β antioxidant effects may neutralize ROS-based treatments
π Pathways Inhibited or Affected:
- CD38 suppression β preserves NAD+ for immune and mitochondrial function
- NF-ΞΊB and COX-2 inhibition β reduces inflammation and cancer cell survival
- PI3K/Akt inhibition β suppresses tumor growth and proliferation
- MMP downregulation β may inhibit invasion and metastasis
- Supports immune repair, DNA stability, and vascular health
π Final Summary
Diosmetin is a high-value NAD+ protector and immune modulator. In Protocol 2, it is taken at 12:30 PM during the Antioxidant Wave Phase to suppress CD38, protect against immune exhaustion, and reduce residual inflammation and tumor signaling after oxidative attack phases.
At 900 mg, Diosmetin plays a strategic role in maintaining the metabolic and immune recovery environment needed to sustain remission and prevent recurrence.
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