EGCG (Epigallocatechin gallate) is the most active polyphenol in green tea. It’s known for its ability to disrupt cancer metabolism, reduce inflammation, and support detoxification—all while being a potent antioxidant.
In Protocol 2, EGCG is used during the Antioxidant Wave Phase to:
- Protect healthy tissues from oxidative damage
- Inhibit cancer cell growth and detox pathways
- Complement other antioxidants like ALA, Curcumin, and Resveratrol
🔍 EGCG – Protocol 2 Summary
✅ Best Timing:
- 12:30 PM during the Antioxidant Wave Phase (after oxidative kill window ends)
- Do not take in the morning or near B17, radiation, or Artemisinin (can block ROS)
- Can be taken with or without food; absorption improves with healthy fats
💊 Recommended Dose:
- 2000 mg daily, preferably from standardized extract
- Choose caffeine-free or decaffeinated versions to avoid overstimulation
- Optional split dose: 1000 mg at 12:30 PM and 1000 mg at OMAD if needed
⏳ Active Duration in Body:
- Starts acting within 1 hour
- Antioxidant and signaling effects last 4–6 hours
- Not stored long-term; consistent daily intake needed for therapeutic effect
🔁 Redundancy With:
- Overlaps with Curcumin, ALA, Resveratrol in antioxidant function
- Unique metabolic benefits justify inclusion: EGCG is a glutathione inhibitor and AMPK activator
- Avoid taking near oxidative agents (B17, MB, Artemisinin) due to ROS-scavenging properties
📉 Pathways Inhibited or Affected:
- Glutathione depletion in cancer cells – weakens their antioxidant defenses
- PI3K/Akt/mTOR inhibition – blocks cancer growth and survival
- VEGF suppression – reduces blood vessel formation (angiogenesis)
- NF-κB downregulation – anti-inflammatory and anti-proliferative
- AMPK activation – mimics fasting, promotes autophagy and metabolic disruption
🔒 Final Summary
EGCG is a dual-action antioxidant and metabolic modulator. In Protocol 2, it’s taken at 12:30 PM during the Antioxidant Wave Phase to suppress cancer growth signals, reduce glutathione in tumors, and protect healthy tissue from radiation or oxidative damage.
Properly timed, EGCG is a powerful recovery-phase ally that reinforces the anti-cancer environment while preserving the effect of earlier oxidative strikes.
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