Honokiol is a bioactive compound extracted from the bark of Magnolia officinalis. It is both lipid-soluble (crosses mitochondrial and blood-brain barriers) and non-toxic, with proven anti-cancer, anti-inflammatory, anti-metastatic, and neuroprotective effects.
In Protocol 2, 500 mg of Honokiol is taken during the OMAD phase to:
- Suppress multiple tumor survival pathways
- Support mitochondrial apoptosis
- Inhibit angiogenesis and metastasis
- Calm the nervous system and reduce stress-related immune suppression
🔍 Honokiol – OMAD Phase Summary
✅ Best Timing:
- 2:30–4:30 PM with the OMAD + Second Wave supplements and meal
- Take with healthy fats (e.g., Black Seed Oil, MCT Oil) to maximize absorption
- Do not take during oxidative therapy hours (early morning); it has antioxidant properties
💊 Recommended Dose:
- 500 mg once daily of high-purity Honokiol (standardized extract or liposomal preferred)
- May increase to 1000 mg/day for advanced cancer or during immune rebuilding (e.g., Weeks 9–12)
- Safe for long-term use
⏳ Active Duration in Body:
- Absorbed within 1–2 hours; peak effects around 2–4 hours post-ingestion
- Active mitochondrial and anti-inflammatory effects last 8–10 hours
- Cumulative benefits build with continuous daily use
🔁 Redundancy With:
- Some overlap with Resveratrol, Curcumin, and EGCG in anti-inflammatory function
- Unique in its mitochondrial penetration, GABAergic calm, and anti-metastatic properties
- Excellent for synergy with Dandelion Root, Luteolin, and Diosmetin in the recovery stack
📉 Pathways Inhibited or Affected:
- NF-κB inhibition – lowers inflammation and immune suppression
- PI3K/Akt/mTOR inhibition – reduces tumor growth and metabolic resilience
- STAT3 inhibition – blocks immune evasion
- Angiogenesis suppression (VEGF) – cuts off tumor blood supply
- Mitochondrial apoptosis promotion – helps initiate cancer cell death
- GABA receptor activation – reduces anxiety and cortisol, supporting immune recovery
🔒 Final Summary
Honokiol is a mitochondrial assassin and immune ally. In Protocol 2, it is taken at 500 mg during the OMAD phase to extend anti-cancer pressure into the afternoon, calm the system, and protect against hidden inflammation and metastasis.
Its rare combination of tumor inhibition, neuroprotection, and mitochondrial penetration makes it a keystone in long-term cancer control and relapse prevention.
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